# Functional Classification Catalogue Version 2.0 18.03.2004 01 METABOLISM 01.01 amino acid metabolism 01.01.03 assimilation of ammonia, metabolism of the glutamate group 01.01.03.01 metabolism of glutamine 01.01.03.01.01 biosynthesis of glutamine 01.01.03.01.02 degradation of glutamine 01.01.03.02 metabolism of glutamate 01.01.03.02.01 biosynthesis of glutamate 01.01.03.02.02 degradation of glutamate 01.01.03.03 metabolism of proline 01.01.03.03.01 biosynthesis of proline 01.01.03.03.02 degradation of proline 01.01.03.04 metabolism of 4-hydroxyproline 01.01.03.04.01 biosynthesis of 4-hydroxyproline 01.01.03.04.02 degradation of 4-hydroxyproline 01.01.03.05 metabolism of arginine 01.01.03.05.01 biosynthesis of arginine 01.01.03.05.02 degradation of arginine 01.01.05 metabolism of urea cycle, creatine and polyamines 01.01.05.01 metabolism of polyamines 01.01.05.01.01 biosynthesis of polyamines 01.01.05.01.02 degradation of polyamines 01.01.05.02 metabolism of creatine 01.01.05.02.01 biosynthesis of creatine 01.01.05.02.02 degradation of creatine 01.01.05.03 metabolism of urea (urea cycle) 01.01.06 metabolism of the aspartate family 01.01.06.01 metabolism of aspartate 01.01.06.01.01 biosynthesis of aspartate 01.01.06.01.02 degradation of aspartate 01.01.06.02 metabolism of asparagine 01.01.06.02.01 biosynthesis of asparagine 01.01.06.02.02 degradation of asparagine 01.01.06.04 metabolism of threonine 01.01.06.04.01 biosynthesis of threonine 01.01.06.04.02 degradation of threonine 01.01.06.05 metabolism of methionine 01.01.06.05.01 biosynthesis of methionine 01.01.06.05.01.01 biosynthesis of homocysteine 01.01.06.05.01.02 degradation of homocysteine 01.01.06.05.02 degradation of methionine 01.01.06.06 metabolism of lysine 01.01.06.06.01 biosynthesis of lysine 01.01.06.06.01.01 diaminopimelic acid pathway 01.01.06.06.01.03 aminoadipic acid pathway 01.01.06.06.02 degradation of lysine 01.01.09 metabolism of the cysteine - aromatic group 01.01.09.01 metabolism of glycine 01.01.09.01.01 biosynthesis of glycine 01.01.09.01.02 degradation of glycine 01.01.09.02 metabolism of serine 01.01.09.02.01 biosynthesis of serine 01.01.09.02.02 degradation of serine 01.01.09.03 metabolism of cysteine 01.01.09.03.01 biosynthesis of cysteine 01.01.09.03.02 degradation of cysteine 01.01.09.04 metabolism of phenylalanine 01.01.09.04.01 biosynthesis of phenylalanine 01.01.09.04.02 degradation of phenylalanine 01.01.09.05 metabolism of tyrosine 01.01.09.05.01 biosynthesis of tyrosine 01.01.09.05.02 degradation of tyrosine 01.01.09.06 metabolism of tryptophan 01.01.09.06.01 biosynthesis of tryptophan 01.01.09.06.02 degradation of tryptophan 01.01.09.07 metabolism of histidine 01.01.09.07.01 biosynthesis of histidine 01.01.09.07.02 degradation of histidine 01.01.11 metabolism of the pyruvate family (alanine, isoleucine, leucine, valine) and D-alanine 01.01.11.01 metabolism of alanine 01.01.11.01.01 biosynthesis of alanine 01.01.11.01.02 degradation of alanine 01.01.11.02 metabolism of isoleucine 01.01.11.02.01 biosynthesis of isoleucine 01.01.11.02.02 degradation of isoleucine 01.01.11.03 metabolism of valine 01.01.11.03.01 biosynthesis of valine 01.01.11.03.02 degradation of valine 01.01.11.04 metabolism of leucine 01.01.11.04.01 biosynthesis of leucine 01.01.11.04.02 degradation of leucine 01.01.11.06 metabolism of the D-alanine amino acid group 01.01.11.07 metabolism of the hydroxyamino acid group 01.01.13 regulation of amino acid metabolism 01.02 nitrogen and sulfur metabolism 01.02.01 nitrogen and sulfur utilization 01.02.01.01 nitrogen fixation 01.02.01.02 nitrate assimilation 01.02.01.03 nitrate dissimilation 01.02.01.05 ammonium nitrification 01.02.01.06 assimilation of ammonia 01.02.01.07 nitric oxide biosynthesis 01.02.01.09 catabolism of nitrogenous compounds 01.02.01.09.01 urea catabolism (not urea cycle) 01.02.01.09.03 urate catabolism 01.02.01.09.05 cyanate catabolism 01.02.01.09.06 anthranilate catabolism 01.02.01.09.07 formamide catabolism 01.02.01.09.08 nitriles catabolism 01.02.01.11 sulfate assimilation 01.02.01.13 assimilatory reduction of sulfur 01.02.01.14 conjunction of sulfate 01.02.01.15 oxidation of sulfur to sulfate, electron as energy source 01.02.01.16 sulfate dissimilation, anaerobic respiration, sulfate respiration 01.02.04 regulation of nitrogen and sulphur utilization 01.02.04.01 regulation of nitrogen utilization 01.02.04.03 regulation of sulfur utilization 01.03 nucleotide metabolism 01.03.01 purine nucleotide metabolism 01.03.01.01 purine nucleotide catabolism 01.03.01.01.01 hypoxanthine catabolism 01.03.01.01.03 xanthine catabolism 01.03.01.03 purine nucleotide anabolism 01.03.04 pyrimidine nucleotide metabolism 01.03.04.01 pyrimidine nucleotide catabolism 01.03.04.03 pyrimidine nucleotide anabolism 01.03.07 deoxyribonucleotide metabolism 01.03.10 metabolism of cyclic and unusual nucleotides 01.03.13 regulation of nucleotide metabolism 01.03.16 polynucleotide degradation 01.03.16.01 RNA degradation 01.03.16.03 DNA degradation 01.04 phosphate metabolism 01.04.01 phosphate utilization 01.04.04 regulation of phosphate utilization 01.05 C-compound and carbohydrate metabolism 01.05.01 C-compound and carbohydrate utilization 01.05.01.01 C-compound, carbohydrate catabolism 01.05.01.01.01 sugar, glucoside, polyol and carboxylate catabolism 01.05.01.01.02 polysaccharide degradation 01.05.01.01.03 C-2 compound and organic acid catabolism 01.05.01.01.04 aminosaccharide catabolism 01.05.01.01.05 C-1 compound catabolism 01.05.01.01.05.01 serine-isocitrate lyase pathway 01.05.01.01.05.03 ribulose-monophosphate cycle 01.05.01.01.07 aliphatic hydrocarbon catabolism 01.05.01.01.09 aerobic aromate catabolism 01.05.01.01.09.01 ortho-cleavage 01.05.01.01.09.03 meta-cleavage 01.05.01.01.11 anaerobic aromate catabolism 01.05.01.03 C-compound, carbohydrate anabolism 01.05.01.03.01 sugar, glucoside, polyol and carboxylate anabolism 01.05.01.03.02 polysaccharide biosynthesis 01.05.01.03.02.01 glycogen biosynthesis 01.05.01.03.02.02 peptidoglycan biosynthesis 01.05.01.03.02.03 chitin biosynthesis 01.05.01.03.02.04 starch biosynthesis 01.05.01.03.03 C-2 compound and organic acid anabolism 01.05.01.03.04 aminosaccharide biosynthesis 01.05.01.03.05 C-1 compound anabolism 01.05.01.03.07 aliphatic hydrocarbon anabolism 01.05.01.03.09 aromate anabolism 01.05.01.05 autotrophic CO2-fixation 01.05.01.05.01 Calvin cycle 01.05.01.05.03 reductive TCA cycle 01.05.01.05.05 hydroxypropionate pathway 01.05.01.05.07 acetyl-CoA pathway 01.05.01.07 transfer of activated C-1 groups 01.05.01.07.01 S-adenosyl-methionine - homocysteine cycle 01.05.01.07.03 tetrahydrofolate-dependent C-1-transfer 01.05.04 regulation of C-compound and carbohydrate utilization 01.06 lipid, fatty acid and isoprenoid metabolism 01.06.01 lipid, fatty acid and isoprenoid biosynthesis 01.06.01.01 phospholipid biosynthesis 01.06.01.03 glycolipid biosynthesis 01.06.01.05 fatty acid biosynthesis 01.06.01.07 isoprenoid biosynthesis 01.06.01.07.01 hemiterpenes biosynthesis 01.06.01.07.03 monoterpenes biosynthesis 01.06.01.07.05 sesquiterpenes biosynthesis 01.06.01.07.07 diterpenes biosynthesis 01.06.01.07.09 triterpenes biosynthesis 01.06.01.07.11 tetracyclic and pentacyclic triterpenes (cholesterin, steroids and hopanoids) biosynthesis 01.06.01.07.13 tetraterpenes (carotinoids) biosynthesis 01.06.01.07.15 polyterpenes biosynthesis 01.06.04 degradation of lipids, fatty acids and isoprenoids 01.06.04.01 phospholipid degradation 01.06.04.03 glycolipid degradation 01.06.04.05 fatty acid degradation (alpha- and beta-oxidation) 01.06.04.07 isoprenoid degradation 01.06.07 lipid, fatty acid and isoprenoid utilization 01.06.10 regulation of lipid, fatty acid and isoprenoid metabolism 01.07 metabolism of vitamins, cofactors, and prosthetic groups 01.07.01 biosynthesis of vitamins, cofactors, and prosthetic groups 01.07.03 catabolism of vitamins, cofactors, and prosthetic groups 01.07.04 utilization of vitamins, cofactors, and prosthetic groups 01.07.07 regulation of vitamins, cofactors, and prosthetic groups metabolism 01.20 secondary metabolism 01.20.01 metabolism of primary metabolic sugars derivatives 01.20.01.01 biosynthesis of secondary monosaccharides 01.20.01.03 biosynthesis of sugar carboxylic acids 01.20.01.05 biosynthesis of sugar alcohols 01.20.01.07 biosynthesis of glycosides 01.20.01.09 biosynthesis of aminoglycoside antibiotics 01.20.03 biosynthesis of derivatives of intermediates of glucose degradation 01.20.05 biosynthesis of acetic acid derivatives 01.20.05.01 biosynthesis of acetoacetate, acetone, hydroxybutyric acid 01.20.05.03 biosynthesis of alkanes, alkenes, alkanals, alkanols 01.20.05.05 biosynthesis of fatty acid esters 01.20.05.07 biosynthesis of acetylenes 01.20.05.09 biosynthesis of eicosanoids 01.20.05.11 biosynthesis of polyketides 01.20.07 biosynthesis of propionic acid derivatives 01.20.09 biosynthesis of derivatives of intermediates of the TCA and glyoxylate pathway 01.20.13 biosynthesis of derivatives of homoisopentenyl pyrophosphate 01.20.15 biosynthesis of derivatives of dehydroquinic acid, shikimic acid and chorismic acid 01.20.15.01 biosynthesis of naphthoquinone, anthraquinone 01.20.15.03 biosynthesis of ubiquinone 01.20.17 biosynthesis of secondary products derived from primary amino acids 01.20.17.01 biosynthesis of nonprotein amino acids 01.20.17.03 biosynthesis of amines 01.20.17.05 biosynthesis of cyanogenic glycosides 01.20.17.07 biosynthesis of glycosinolates and derivatives 01.20.17.09 biosynthesis of alkaloids 01.20.19 biosynthesis of secondary products derived from glycine, L-serine and L-alanine 01.20.19.01 biosynthesis of porphyrins 01.20.19.03 biosynthesis of open-chain tetrapyrrols 01.20.19.05 biosynthesis of cobalamins 01.20.21 biosynthesis of sulfuric acid and L-cysteine derivatives 01.20.23 biosynthesis of secondary products derived from L-methionine 01.20.25 biosynthesis of secondary products derived from L-valin, L-leucin and L-isoleucin 01.20.27 biosynthesis of secondary products derived from L-aspartic acid and L-threonine 01.20.29 biosynthesis of secondary products derived from L-glutamic acid, L-proline and L-ornithine 01.20.31 biosynthesis of secondary products derived from L-lysine, L-arginine and L-histidine 01.20.33 biosynthesis of secondary products derived from L-tryptophan 01.20.35 biosynthesis of secondary products derived from L-phenylalanine and L-tyrosine 01.20.35.01 biosynthesis of phenylpropanoids 01.20.35.01.01 biosynthesis of melanins 01.20.35.01.03 biosynthesis of lignins 01.20.35.01.05 biosynthesis of stilbenes, flavonoids 01.20.35.01.07 biosynthesis of coumarins 01.20.35.01.09 biosynthesis of cinnamic acids 01.20.35.02 biosynthesis of thyroids 01.20.35.03 biosynthesis of catecholamines 01.20.36 non-ribosomal peptide synthesis 01.20.37 biosynthesis of peptide derived compounds 01.20.37.01 biosynthesis of thioredoxin, glutaredoxin, glutathion 01.20.37.03 biosynthesis of peptide antibiotics 01.20.37.05 biosynthesis of beta-lactams 01.20.50 catabolism of secondary metabolites 01.20.70 regulation of secondary metabolism 01.25 extracellular metabolism 01.25.01 extracellular polysaccharide degradation 01.25.03 extracellular protein degradation 01.25.05 extracellular polynucleotide degradation 01.25.07 extracellular ester compound degradation 01.25.09 extracellular lignin degradation 01.25.11 extracellular aminosaccharide degradation 02 ENERGY 02.01 glycolysis and gluconeogenesis 02.01.01 glycolysis methylglyoxal bypass 02.01.03 regulation of glycolysis and gluconeogenesis 02.04 glyoxylate cycle 02.05 Entner-Doudoroff pathway 02.07 pentose-phosphate pathway 02.07.01 pentose-phosphate pathway oxidative branch 02.07.03 pentose-phosphate pathway non oxidative branch 02.07.05 regulation of pentose-phosphate pathway 02.08 pyruvate dehydrogenase complex 02.09 anaplerotic reactions 02.10 tricarboxylic-acid pathway (citrate cycle, Krebs cycle, TCA cycle) 02.11 electron transport and membrane-associated energy conservation 02.11.05 accessory proteins of electron transport and membrane-associated energy conservation 02.11.07 regulation of electron transport and membrane-associated energy conservation 02.13 respiration 02.13.01 anaerobic respiration 02.13.03 aerobic respiration 02.13.05 regulation of respiration 02.16 fermentation 02.16.01 alcohol fermentation 02.16.01.01 bacterial type ethanol fermentation 02.16.03 lactate fermentation 02.16.03.01 homofermentative pathway 02.16.03.03 heterofermentative pathway and fermentaton of other saccharides 02.16.03.05 bifidum pathway 02.16.03.07 malo-lactate fermentation 02.16.05 butyrate and butanol-acetoine fermentation 02.16.07 ethanol-acetate fermentation 02.16.09 mixed acid and butanediol fermentation 02.16.11 propionate fermentation 02.16.11.01 acrylate pathway 02.16.11.03 succinate-propionate pathway 02.16.13 acetate fermentation 02.16.15 methane fermentation 02.16.17 fermentation of nitrogenous compounds 02.16.17.01 single amino acid fermentations 02.16.17.03 stickland reactions 02.16.17.05 fermentation of heterocyclic compounds 02.16.20 regulation of fermentation 02.17 chemolithotrophie (e.g. sulfide, nitrogenous compounds) 02.19 metabolism of energy reserves (e.g. glycogen, trehalose) 02.25 oxidation of fatty acids 02.30 photosynthesis 02.30.01 anoxygenic photosynthesis 02.30.03 oxygenic photosynthesis 02.30.07 accessory proteins of photosynthetic electron transport 02.30.10 regulation of photosynthesis 02.45 energy conversion and regeneration 02.45.01 bioluminescence 02.45.03 light absorption 02.45.07 heat production 02.45.11 conversion to kinetic energy (e.g. movement) 02.45.15 energy generation (e.g. ATP synthase) 02.45.20 regulation of energy conversion / regeneration 04 STORAGE PROTEIN 04.01 storage facilitating proteins 04.02 stored proteins 10 CELL CYCLE AND DNA PROCESSING 10.01 DNA processing 10.01.01 cellular DNA uptake 10.01.01.01 bacterial competence 10.01.01.03 conjugational DNA transfer 10.01.03 DNA synthesis and replication 10.01.03.01 DNA topology 10.01.03.03 ori recognition and priming complex formation 10.01.03.05 extension/ polymerization activity 10.01.05 DNA recombination and DNA repair 10.01.05.01 DNA repair 10.01.05.03 DNA recombination 10.01.05.03.01 meiotic recombination 10.01.05.03.03 somatic / mitotic recombination 10.01.05.03.05 DNA integration 10.01.09 DNA restriction or modification 10.01.09.01 DNA methylation 10.01.09.03 DNA restriction 10.01.09.05 DNA conformation modification (e.g. chromatin) 10.01.09.07 DNA imprinting 10.01.11 regulation of DNA processing 10.03 cell cycle 10.03.01 mitotic cell cycle and cell cycle control 10.03.01.01 mitotic cell cycle 10.03.01.01.01 G1 phase of mitotic cell cycle 10.03.01.01.03 G1/S transition of mitotic cell cycle 10.03.01.01.05 S phase of mitotic cell cycle 10.03.01.01.07 G2 phase of mitotic cell cycle 10.03.01.01.09 G2/M transition of mitotic cell cycle 10.03.01.01.11 mitosis 10.03.01.01.13 M/G1 transition of mitotic cell cycle 10.03.01.02 cell cycle arrest 10.03.01.03 cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle) 10.03.02 meiosis 10.03.02.01 meiosis I 10.03.02.03 meiosis II 10.03.03 cytokinesis (cell division) /septum formation 10.03.04 nuclear and chromosomal cycle 10.03.04.01 centromere/kinetochore complex maturation 10.03.04.03 chromosome condensation 10.03.04.05 chromosome segregation/division 10.03.04.06 chromosome inactivation 10.03.04.07 nuclear division 10.03.04.09 nuclear migration 10.03.05 cell cycle dependent cytoskeleton reorganization 10.03.05.01 spindle pole body/centrosome and microtubule cycle 10.03.05.03 cell cycle dependent actin filament reorganization 11 TRANSCRIPTION 11.02 RNA synthesis 11.02.01 rRNA synthesis 11.02.02 tRNA synthesis 11.02.03 mRNA synthesis 11.02.03.01 general transcription activities 11.02.03.01.01 transcription initiation 11.02.03.01.04 transcription elongation 11.02.03.01.07 transcription termination 11.02.03.04 transcriptional control 11.02.03.04.01 transcriptional activator 11.02.03.04.03 transcriptional repressor 11.02.03.04.05 enhancer/silencer interaction 11.02.03.04.07 posttranscriptional control 11.04 RNA processing 11.04.01 rRNA processing 11.04.02 tRNA processing 11.04.03 mRNA processing (splicing, 5'-, 3'-end processing) 11.04.03.01 splicing 11.04.03.01.10 regulation of splicing 11.04.03.03 5'-end processing 11.04.03.05 3'-end processing 11.04.03.11 control of mRNA stability 11.06 RNA modification 11.06.01 rRNA modification 11.06.02 tRNA modification 11.06.03 mRNA modification 11.06.03.01 mRNA editing 12 PROTEIN SYNTHESIS 12.01 ribosome biogenesis 12.01.01 ribosomal proteins 12.04 translation 12.04.01 translation initiation 12.04.02 translation elongation 12.04.03 translation termination 12.07 translational control 12.10 aminoacyl-tRNA-synthetases 14 PROTEIN FATE (folding, modification, destination) 14.01 protein folding and stabilization 14.04 protein targeting, sorting and translocation 14.07 protein modification 14.07.01 modification with fatty acids (e.g. myristylation, palmitylation, farnesylation) 14.07.02 modification with sugar residues (e.g. glycosylation) 14.07.02.01 O-directed glycosylation 14.07.02.02 N-directed glycosylation 14.07.03 modification by phosphorylation, dephosphorylation, autophosphorylation 14.07.04 modification by acetylation, deacetylation 14.07.05 modification by ubiquitination, deubiquitination 14.07.07 modification by ubiquitin-related proteins 14.07.09 posttranslational modification of amino acids (e.g. hydroxylation, methylation) 14.07.11 protein processing (proteolytic) 14.07.11.01 autoproteolytic processing 14.10 assembly of protein complexes 14.13 protein degradation 14.13.01 cytoplasmic and nuclear protein degradation 14.13.01.01 proteasomal degradation (ubiquitin/proteasomal pathway) 14.13.04 lysosomal and vacuolar protein degradation 14.13.04.01 lysosomal protein degradation 14.13.04.02 vacuolar protein degradation 16 PROTEIN WITH BINDING FUNCTION OR COFACTOR REQUIREMENT (structural or catalytic) 16.01 protein binding 16.02 peptide binding 16.03 nucleic acid binding 16.03.01 DNA binding 16.03.03 RNA binding 16.05 polysaccharide binding 16.06 motor protein 16.07 structural protein 16.09 lipid binding 16.11 amino acid binding 16.12 sulfate binding 16.13 C-compound binding 16.13.01 sugar binding 16.13.03 fatty acid binding (e.g. acyl-carrier protein) 16.17 metal binding 16.17.01 calcium binding 16.17.03 potassium binding 16.17.05 sodium binding 16.17.07 magnesium binding 16.17.09 heavy metal binding (Cu, Fe, Zn) 16.19 nucleotide binding 16.19.01 cyclic nucleotide binding (cAMP, cGMP, etc.) 16.19.03 ATP binding 16.19.05 GTP binding 16.21 complex cofactor/cosubstrate binding 16.21.01 heme binding 16.21.03 molybdopterin binding 16.21.05 FAD/FMN binding 16.21.07 NAD/NADP binding 16.21.08 FE/S binding 16.21.09 cobalamin binding 16.21.11 thiamin pyrophosphate binding 16.21.13 lipoamid binding 16.21.15 biotin binding 16.21.17 pyridoxal phosphate binding 18 PROTEIN ACTIVITY REGULATION 18.01 mechanism of regulation 18.01.01 modification 18.01.03 localization 18.01.05 processing 18.01.07 binding / dissociation 18.02 target of regulation 18.02.01 enzymatic activity regulation / enzyme regulator 18.02.01.01 enzyme activator 18.02.01.01.01 GTPase activator (GAP) 18.02.01.01.03 protease activator 18.02.01.01.05 kinase activator 18.02.01.02 enzyme inhibitor 18.02.01.02.01 GTPase inhibitor (GIP) 18.02.01.02.03 protease inhibitor 18.02.01.02.05 kinase inhibitior 18.02.03 guanyl-nucleotide exchange factor (GEF) 18.02.05 regulator of G-protein signalling 18.02.07 regulator of receptor activity 18.02.09 regulator of transcription factor 20 CELLULAR TRANSPORT, TRANSPORT FACILITATION AND TRANSPORT ROUTES 20.01 transported compounds (substrates) 20.01.01 ion transport 20.01.01.01 cation transport (Na, K, Ca , NH4, etc.) 20.01.01.01.01 heavy metal ion transport (Cu, Fe, etc.) 20.01.01.01.01.01 siderophore-iron transport 20.01.01.01.01.02 citrate-iron transport 20.01.01.07 anion transport (Cl, SO4, PO4, etc.) 20.01.01.07.01 nitrate transport 20.01.01.07.03 nitrite transport 20.01.01.07.05 sulfate transport 20.01.01.07.07 phosphate transport 20.01.01.07.09 chloride transport 20.01.03 C-compound and carbohydrate transport 20.01.03.01 sugar transport 20.01.03.03 C4-dicarboxylate transport (e.g. malate, succinate, fumarate) 20.01.07 amino acid transport 20.01.09 peptide transport 20.01.10 protein transport 20.01.11 amine / polyamine transport 20.01.13 lipid transport 20.01.15 electron / hydrogen transport 20.01.17 nucleotide transport 20.01.19 nucleoside transport 20.01.21 RNA transport 20.01.23 allantoin and allantoate transport 20.01.25 vitamin/cofactor transport 20.01.26 neurotransmitter transport 20.01.27 drug transport 20.03 transport facilitation 20.03.01 channel / pore class transport 20.03.01.01 ion channels 20.03.01.03 gap-junction forming protein family (e.g. connexin, innexin) 20.03.01.05 nuclear pore forming protein 20.03.01.07 general bacterial porin family (e.g. ompf, sugar porin, omf) 20.03.01.09 pore-forming toxins (e.g. diphteria toxin, hemolysin) 20.03.03 uniporter 20.03.05 symporters 20.03.05.01 proton driven symporter 20.03.05.03 sodium driven symporter 20.03.07 antiporters 20.03.07.01 proton driven antiporter 20.03.07.03 sodium driven antiporter 20.03.09 phosphotransferase system 20.03.22 transport ATPases 20.03.25 ABC transporters 20.09 transport routes 20.09.01 nuclear transport 20.09.02 chloroplast transport 20.09.04 mitochondrial transport 20.09.05 non-vesicular ER transport 20.09.07 vesicular transport (Golgi network, etc.) 20.09.07.03 ER to Golgi transport 20.09.07.05 intra Golgi transport 20.09.07.06 post Golgi transport 20.09.07.25 vesicle formation 20.09.07.27 vesicle fusion 20.09.07.29 vesicle recycling 20.09.10 peroxisomal transport 20.09.13 vacuolar transport 20.09.14 cytoskeleton-dependent transport 20.09.14.01 tubulin dependent transport 20.09.14.02 actin dependent transport 20.09.16 cellular export and secretion 20.09.16.01 Type I protein secretion system (ABC-type transport systems) 20.09.16.02 Type II protein secretion system (general secretory pathway, exocytosis) 20.09.16.03 Type III protein secretion system (virulence related secretory pathway, Gram- bacteria specific) 20.09.16.04 Type IV protein secretion system (conjugal DNA-protein transfer) 20.09.16.05 Type V protein secretion system (MttABC or TatABCDE-system) 20.09.16.07 non-vesicular cellular export 20.09.16.09 vesicular cellular export 20.09.16.09.03 exocytosis 20.09.16.09.05 synaptic vesicles 20.09.18 cellular import 20.09.18.07 non-vesicular cellular import 20.09.18.09 vesicular cellular import 20.09.18.09.01 endocytosis 20.09.18.09.01.01 receptor-mediated endocytosis 20.09.18.09.01.03 constitutive endocytosis 30 CELLULAR COMMUNICATION/SIGNAL TRANSDUCTION MECHANISM 30.01 intracellular signalling 30.01.01 unspecified signal transduction 30.01.05 enzyme mediated signal transduction 30.01.05.01 protein kinase cascades 30.01.05.01.01 JAK-STAT cascade 30.01.05.01.02 JNK cascade 30.01.05.01.03 MAPKKK cascade 30.01.05.01.04 NIK-I-kappaB/NF-kappaB cascade 30.01.05.03 protease mediated signal transduction 30.01.05.05 G-protein mediated signal transduction 30.01.05.05.01 small GTPase mediated signal transduction 30.01.05.05.03 trimeric G-protein mediated signal transduction 30.01.05.07 two-component signal transduction system (e.g. phosphorelay) 30.01.09 second messenger mediated signal transduction 30.01.09.01 NO mediated signal transduction 30.01.09.03 Ca2+ mediated signal transduction 30.01.09.07 cAMP mediated signal transduction 30.01.09.08 hormone mediated signal transduction 30.01.09.09 fatty acid derivatives mediated signal transduction 30.01.09.11 polyphosphoinositol mediated signal transduction 30.01.11 ligand-dependent nuclear receptors 30.05 transmembrane signal transduction 30.05.01 receptor enzyme mediated signalling 30.05.01.05 interleukine receptor signalling pathway 30.05.01.10 two-component signal transduction system (sensor kinase component) 30.05.01.12 transmembrane receptor protein tyrosine kinase signalling pathways 30.05.01.12.01 EGF-receptor signalling pathway 30.05.01.12.03 FGF-receptor signalling pathway 30.05.01.12.04 IGF-receptor signalling pathway 30.05.01.12.05 insulin receptor signalling pathway 30.05.01.18 transmembrane receptor protein serine/threonine kinase signalling pathways 30.05.01.18.01 TGF-beta-receptor signalling pathway 30.05.02 non-enzymatic receptor mediated signalling 30.05.02.14 Notch-receptor signalling pathway 30.05.02.16 hedgehog-dependent signalling pathway 30.05.02.20 wnt signalling pathway 30.05.02.22 Tl-receptor (LRR proteins) signalling pathway 30.05.02.24 G-protein coupled receptor signalling pathway 30.05.02.24.01 serotonin receptor signalling pathway 30.05.02.24.02 acetyl choline receptor signalling pathway 30.05.02.24.03 dopamine receptor signalling pathway 30.05.02.24.04 gamma-aminobutyric acid signalling pathway 30.05.02.24.05 glutamate signalling pathway 30.05.02.24.06 neuropeptide signalling pathway 30.05.02.26 integrin receptor signalling pathway 30.05.02.28 cadherin mediated signalling pathway 30.05.02.30 ion channel mediated signalling pathway 32 CELL RESCUE, DEFENSE AND VIRULENCE 32.01 stress response 32.01.01 oxydative stress response 32.01.03 osmotic and salt stress response 32.01.04 pH stress response 32.01.05 heat shock response 32.01.06 cold shock response 32.01.07 unfolded protein response (ER quality control) 32.01.09 DNA damage response 32.01.11 nutrient starvation response 32.01.13 electromagnetic waves stress response (e.g. UV, X-ray) 32.05 disease, virulence and defense 32.05.01 resistance proteins 32.05.01.01 antibiotic resistance 32.05.01.03 chemical agent resistance 32.05.01.03.01 organic chemical agent resistance 32.05.01.03.03 inorganic chemical agent resistance (e.g. heavy metals) 32.05.01.05 bacteriocine resistance 32.05.01.07 electromagnetic waves resistance (e.g. UV) 32.05.03 defense related proteins 32.05.05 virulence, disease factors 32.05.05.01 toxins 32.05.05.03 bacteriocins 32.05.05.05 invasins 32.05.05.06 internalins 32.05.05.07 adhaesins 32.05.05.08 cytolysins 32.05.05.09 evasion of host immune system 32.05.05.13 antigenic determinants 32.07 detoxification 32.07.01 detoxification involving cytochrome P450 32.07.03 detoxification by modification 32.07.05 detoxification by export 32.07.07 oxygen and radical detoxification 32.07.07.01 catalase reaction 32.07.07.03 glutathione conjugation reaction 32.07.07.05 peroxidase reaction 32.07.07.07 superoxide metabolism 32.07.09 detoxification by degradation 32.07.11 detoxification by impermeability 32.10 degradation of foreign (exogenous) compounds 32.10.03 degradation of foreign (exogenous) polynucleotides 32.10.05 degradation of foreign (exogenous) proteins 32.10.07 degradation of foreign (exogenous) polysaccharides 32.10.09 degradation of foreign (exogenous) ester compounds 34 INTERACTION WITH THE CELLULAR ENVIRONMENT 34.01 ionic homeostasis 34.01.01 homeostasis of cations 34.01.01.01 homeostasis of metal ions (Na, K, Ca etc.) 34.01.01.03 homeostasis of protons 34.01.03 homeostasis of anions 34.01.03.01 homeostasis of sulfates 34.01.03.03 homeostasis of phosphate 34.01.03.05 homeostasis of chloride 34.03 membrane excitability 34.03.01 synaptic transmission 34.03.03 regulation, generation and propagation of action potential 34.05 cell motility 34.05.01 cell migration 34.05.07 ciliary/flagellar motility 34.05.09 polymerization based motility 34.07 cell adhesion 34.07.01 cell-cell adhesion 34.07.02 cell-matrix adhesion 34.11 cellular sensing and response 34.11.01 photoperception and response 34.11.01.01 light environment response 34.11.01.03 visual transduction 34.11.01.05 phototaxis 34.11.03 chemoperception and response 34.11.03.01 perception of nutrients and nutritional adaptation 34.11.03.03 chemotaxis 34.11.03.05 chemical environment response 34.11.03.07 pheromone response, mating-type determination, sex-specific proteins 34.11.03.07.01 incompatibility 34.11.03.11 pH response 34.11.03.13 osmosensing 34.11.03.15 quorum sensing system 34.11.05 mechanical stimulus perception and response 34.11.07 gravity perception and response 34.11.08 electromagnetic field perception and response 34.11.09 temperature perception and response 34.11.11 rhythm (e.g. circadian, ultradian) 36 INTERACTION WITH THE ENVIRONMENT (Systemic) 36.03 nutrients uptake and absorption (e.g. digestion) 36.05 osmoregulation and excretion 36.07 gas and metabolite distribution 36.07.01 gas exchange and distribution 36.07.03 control of respiratory activity 36.07.05 metabolite distribution 36.07.07 circulation 36.09 systemic temperature regulation 36.11 systemic rhythm control 36.20 plant / fungal specific systemic sensing and response 36.20.16 plant defense response 36.20.16.01 disease resistance (R-gene) specific 36.20.16.03 jasmonic acid/ethylene dependent systemic resistance 36.20.16.05 systemic acquired resistance 36.20.16.07 hypersensitive response 36.20.18 plant hormonal regulation 36.20.18.01 auxin response 36.20.18.02 ethylen response 36.20.18.03 gibberellic acid response 36.20.18.04 cytokinin response 36.20.18.05 abscisic acid response 36.20.18.06 brassinosteroid response 36.20.18.99 other plant signalling molecules response (jasmonic acid, salicylic acid etc.) 36.20.35 response to environmental stimuli 36.20.35.09 chemical environment sensing and response 36.20.35.09.01 water response and homeostasis 36.20.35.09.03 pH response 36.20.35.09.05 osmotic response 36.20.35.09.07 chemotropism 36.20.35.11 light sensing and response 36.20.35.11.01 phototropism 36.20.35.13 gravity sensing and response 36.20.35.13.01 gravitropism 36.20.35.15 mechanical stimulus response 36.25 animal specific systemic sensing and response 36.25.01 animal sensory mechanisms 36.25.01.01 vision 36.25.01.03 hearing 36.25.01.05 tactile sense (peripheral physical and mechanical stimuli perception) 36.25.01.07 sense of balance and equilibrium (vestibular pathways and mechanisms) 36.25.01.09 proprioceptive pathways and mechanisms 36.25.01.11 taste 36.25.01.13 olfaction 36.25.01.15 pain (nociceptive pathways) 36.25.03 nervous system physiology 36.25.03.01 nervous system mediated vegetative activities / neurosecretory activities 36.25.03.01.01 effect on glands / hormones 36.25.03.01.03 effect on smooth muscles 36.25.03.01.05 effect on heart muscle 36.25.03.03 nervous system mediated motor activity 36.25.03.03.01 neuromuscular junction-related activities 36.25.03.03.03 movement and posture coordination 36.25.03.04 neuronal integrative functions 36.25.03.04.01 learning and memory 36.25.07 animal hormonal regulation 36.25.07.01 effect on kinetics (muscle contraction, pigment, gland secretion) 36.25.07.03 effect on homeostasis (e.g. metabolism or electrolyte homeostasis) 36.25.07.05 effect on morphogenesis 36.25.07.07 effect on behaviour 36.25.09 muscle contraction 36.25.09.01 smooth muscle contraction 36.25.09.03 striated muscle contraction 36.25.09.05 general muscle contraction regulation 36.25.16 immune response 36.25.16.01 innate immune response (invertebrates and vertebrates) 36.25.16.01.01 complement response 36.25.16.01.03 phagocyte response (e.g. macrophages, dendritic cells, granulocytes) 36.25.16.01.05 cytotoxic cell response (e.g. NK) 36.25.16.01.07 acute phase response (C-reactive protein) 36.25.16.03 adaptive immune response (vertebrates) 36.25.16.03.01 humoral response (B-cells) 36.25.16.03.03 adaptive cell mediated response (T-cells) 36.25.16.03.05 antigen presentation / processing 36.25.16.03.07 immunological memory 36.25.16.07 inflammatory response 36.25.16.09 blood coagulation 38 TRANSPOSABLE ELEMENTS, VIRAL AND PLASMID PROTEINS 38.01 LTR retroelements (retroviral) 38.02 non-LTR retroelements 38.03 transposons 38.05 viral proteins 38.06 phage proteins 38.07 proteins necessary for the integration or inhibition of transposon movement 40 CELL FATE 40.01 cell growth / morphogenesis 40.01.01 non-directional cell growth 40.01.03 directional cell growth (morphogenesis) 40.01.03.01 regulation of directional cell growth 40.01.03.03 guidance of longitudinal cell extension (e.g. pollen tube guidance, axonal pathfinding) 40.01.05 growth regulators / regulation of cell size 40.01.05.01 interpretation of external signals that control cell growth 40.01.05.02 interpretation of nuclear/cytoplasmic ratio to control cell growth 40.02 cell differentiation 40.02.03 extracellular differentiation regulators 40.02.03.01 cytokines (interleukines, colony stimulating factors, etc.) 40.02.03.03 chemokines 40.02.03.05 growth factors 40.02.03.07 trophic factors 40.05 dedifferentiation 40.10 cell death 40.10.02 apoptosis (type I programmed cell death) 40.10.02.01 anti-apoptosis 40.10.02.02 apoptotic program 40.10.02.02.01 apoptotic mitochondrial changes 40.10.02.02.02 caspase activation 40.10.02.02.03 disassembly of cell structures 40.10.02.02.04 induction of proapoptotic gene products 40.10.02.02.05 repression of survival gene products 40.10.02.03 induction of apoptosis 40.10.02.03.01 induction of apoptosis by extracellular signals 40.10.02.03.02 induction of apoptosis by intracellular signals 40.10.90 other programmed cell death 40.20 cell aging 41 DEVELOPMENT (Systemic) 41.01 fungal/microorganismic development 41.01.01 mating (fertilization) 41.01.03 tissue pattern formation 41.01.03.01 fruit body development (sexually or asexually derived spores) 41.01.03.03 mycelium development (hyphae, vegetative thallus) 41.03 plant development 41.03.01 gametophyte development 41.03.01.01 microspore development (male gametophyte) 41.03.01.02 macrospore development (female gametophyte) 41.03.02 fertilization (pollen hydration, pollen tube guidance, double fertilization of oocyte and endosperm) 41.03.03 embryonal development 41.03.03.01 zygote development 41.03.03.02 early embryo development (Dicotyledone pre-heart stages) 41.03.03.03 mid-stage embryo development (Dicotyledone heart to torpedo) 41.03.03.04 late-stage embryo development (Dicotyledone torpedo and later) 41.03.03.05 mature embryo development 41.03.04 endosperm development 41.03.05 germination 41.03.06 vegetative development 41.03.07 flower development 41.03.08 fruit development and ripening 41.03.10 senescence 41.05 animal development 41.05.01 fertilization 41.05.02 embryo implantation (mammalia) 41.05.03 early embryonic development 41.05.03.01 morula development 41.05.03.03 blastocyst (mammalia) 41.05.03.03.01 trophectoderm 41.05.03.03.03 inner cell mass 41.05.03.05 blastocoel development 41.05.03.07 blastulation 41.05.09 gastrulation 41.05.10 late embryonic development 41.05.11 extraembryonal tissue development 41.05.13 neurogenesis 41.05.15 myogenesis 41.05.17 osteogenesis 41.05.19 asymmetries and axis determination 41.05.19.01 vegetal pole determination 41.05.19.03 animal pole determination 41.05.19.05 anterior-posterior axis determination 41.05.19.07 dorso-ventral axis determination 41.05.19.09 medio-lateral axis determination 41.05.19.11 segment specification 41.05.21 extremities and appendages development 41.05.23 sex differentiation 41.05.25 gametogenesis 42 BIOGENESIS OF CELLULAR COMPONENTS 42.01 cell wall 42.02 eukaryotic plasma membrane 42.02.01 eukaryotic intracellular plasma membrane 42.03 cytoplasm 42.04 cytoskeleton 42.04.03 actin cytoskeleton 42.04.05 microtubule cytoskeleton 42.04.07 intermediate filaments 42.05 centrosome 42.06 cell junction 42.06.03 cell-substrate adherens junction 42.06.04 intercellular junction (gap junction/adherens junction) 42.07 endoplasmic reticulum 42.08 Golgi 42.09 intracellular transport vesicles 42.10 nucleus 42.10.03 organization of chromosome structure 42.10.04 centromere / kinetochore 42.10.05 nuclear membrane 42.10.06 nuclear matrix 42.10.07 nucleolus 42.10.09 nuclear speckles 42.16 mitochondrion 42.19 peroxisome 42.22 endosome 42.25 vacuole or lysosome 42.26 plastid 42.26.03 chloroplast 42.26.05 amyloplast 42.26.07 chromoplast 42.26.09 elaioplast 42.26.11 etioplast 42.26.13 leucoplast 42.27 extracellular / secretion proteins 42.27.01 extracellular matrix 42.27.03 cell membrane or cell wall attached 42.28 periplasmatic space 42.29 bud / growth tip 42.30 prokaryotic cytoplasmic membrane 42.32 flagellum 42.33 pilus/fimbria 42.34 prokaryotic cell envelope structures 42.34.01 bacterial outer membrane (only in Gram- bacteria) 42.34.03 capsule and slime layer 42.34.05 S-Layer 42.34.07 peptidoglycan layer or other prokaryotic cell wall 42.34.09 spore or cyst coat 42.35 prokaryotic intracytoplasmic membrane 42.35.03 prokaryotic vesicular intracytoplasmic membrane 42.35.05 prokaryotic tubular intracytoplasmic membrane 42.35.07 prokaryotic thylakoid-like and thylakoid membrane 42.36 prokaryotic cell inclusions 42.37 prokaryotic nucleoid 43 CELL TYPE DIFFERENTIATION 43.01 fungal/microorganismic cell type differentiation 43.01.02 prokaryotic cell type differentiation 43.01.02.01 development free living cell or mycelium 43.01.02.02 development of sporangia and cystophore 43.01.02.03 development of heterocyste 43.01.02.05 sporulation and other development of resting stage 43.01.02.05.01 development of endospore 43.01.02.05.03 development of exospore, cyst, akinete or other resting cell 43.01.02.07 germination from resting stage 43.01.02.09 development of stalked or other sessile cell 43.01.02.11 development of swarmer or other mobile cell 43.01.02.13 biofilm development 43.01.03 fungal and other eukaryotic cell type differentiation 43.01.03.01 development of free swimming or amoeboid cell 43.01.03.02 development of mycelial or yeast-like cell 43.01.03.03 development of thallic, plasmodial or sporangiophore cell 43.01.03.05 budding, cell polarity and filament formation 43.01.03.06 hyphae formation 43.01.03.07 development of conidia 43.01.03.09 development of asco- basidio- or zygospore 43.01.06 protist cell differentiation 43.02 plant cell type differentiation 43.02.01 stem cell/meristematic cell 43.02.05 epidermal cell 43.02.05.01 stomata/guard cell 43.02.05.02 plant hair cell (trichome e.g. cotton) 43.02.05.03 root hair 43.02.07 storage cell 43.02.09 vascular cell 43.02.09.01 sieve cell (phloem) 43.02.09.02 companion cell (phloem) 43.02.09.03 vessel element (xylem) 43.02.11 mesenchymal / parenchymal cell 43.02.13 strengthening cell 43.02.13.01 sclerenchyma cell(dead) 43.02.13.02 collenchyma cell (living) 43.02.17 gametophytic cell 43.02.17.01 male gametophyte 43.02.17.01.01 generative pollen cell 43.02.17.02 female gametophyte 43.02.17.02.01 oocyte 43.02.17.02.03 central cell (2n) 43.02.19 secretory cell 43.03 animal cell type differentiation 43.03.01 stem cell (toti- or pluripotent) 43.03.02 germ cell 43.03.03 pigment cell 43.03.07 oxygen transporting cell (erythrocyte, etc.) 43.03.09 immune cell 43.03.09.01 T-cell 43.03.09.03 B-cell 43.03.09.05 macrophage 43.03.09.07 dendritic cell 43.03.11 glia cell 43.03.13 neuron 43.03.15 secretory cell (mastcell, endocrine cell, etc.) 43.03.17 structural cell of tissue (fibroblast, osteoblast, etc.) 43.03.18 storage cell (lipocyte, etc.) 43.03.19 extracellular matrix forming cell (fibrocyte, chondrocyte, osteocyte) 43.03.21 extracellular matrix degrading cell (chondroclast, osteoclast) 43.03.23 sensory cell 45 TISSUE DIFFERENTIATION 45.01 fungal/microorganismic tissue 45.01.01 reproductive tissue 45.01.10 thallic tissue 45.01.11 plectenchymatic tissue and tissue of primitive thalli (e.g. higher fungi) 45.02 plant tissue 45.02.01 meristematic tissue 45.02.01.01 shoot apical meristem 45.02.01.02 root meristem 45.02.05 parenchyma 45.02.09 dermal tissue 45.02.09.01 epidermis 45.02.09.03 rhizodermis 45.02.09.05 secondary dermal tissue (cork, phellem) 45.02.09.07 endodermis (with casparian band) 45.02.13 vascular tissue 45.02.15 thallus 45.03 animal tissue 45.03.03 proliferative tissue (bone marrow, epidermis, etc.) 45.03.05 connective tissue 45.03.05.01 loose connective tissue / soft tissue 45.03.05.03 fibrous connective tissue (tendons, ligaments) 45.03.05.05 cartilage 45.03.05.07 bone 45.03.05.09 whole blood and lymph 45.03.05.11 adipose tissue 45.03.09 epithelium 45.03.12 muscle 45.03.12.01 striated muscle 45.03.12.02 smooth muscle 45.03.12.03 heart muscle 45.03.15 reproductive tissue 45.03.17 nervous tissue 45.03.19 glandular tissue 47 ORGAN DIFFERENTIATION 47.01 fungal organ 47.01.01 hyphe 47.01.03 reproductive organ 47.01.03.01 fruit body 47.02 plant organ 47.02.01 shoot 47.02.01.01 stem 47.02.01.02 leaf 47.02.01.03 flower 47.02.01.03.01 sepal 47.02.01.03.02 petal 47.02.01.03.03 anther 47.02.01.03.04 carpel 47.02.01.04 fruit 47.02.01.05 seed 47.02.01.05.01 embryo 47.02.01.05.02 endosperm 47.02.01.06 rhizome (potato tuber/onion) 47.02.02 root 47.03 animal organ 47.03.01 nervous system 47.03.01.01 central nervous system 47.03.01.01.01 brain 47.03.01.01.01.01 cerebrum 47.03.01.01.01.02 cerebellum 47.03.01.02 peripheral nervous system 47.03.02 sensory organs 47.03.02.01 ear 47.03.02.02 eye 47.03.02.03 nose 47.03.02.04 tongue 47.03.02.05 skin 47.03.03 vascular organs 47.03.03.01 heart 47.03.03.02 vessels 47.03.05 immune system organs 47.03.05.01 thymus 47.03.05.02 spleen 47.03.05.03 lymphatic system 47.03.07 excretory apparatus 47.03.07.01 kidney 47.03.07.03 malphigi 47.03.07.05 pronephros (sensu Invertebrata) 47.03.07.07 metanephros (sensu Invertebrata) 47.03.09 respiratory system 47.03.09.01 lung 47.03.09.03 gill 47.03.09.05 trachea (sensu Insecta) 47.03.11 gastro-intestinal system 47.03.11.01 teeth 47.03.11.02 oesophagus 47.03.11.03 stomach 47.03.11.05 intestine 47.03.11.07 liver 47.03.11.09 pancreas 47.03.11.11 gastro-intestinal system accessory organs 47.03.13 dermis/cuticula 47.03.13.05 hair / feather follicule 47.03.15 reproductive apparatus 47.03.15.01 female gonad (ovary) 47.03.15.02 oviduct 47.03.15.04 uterus 47.03.15.04.03 cervix 47.03.15.05 placenta 47.03.15.07 male gonad (testis) 47.03.15.09 prostate 47.03.17 skeletal system 47.03.19 non-organ cavities and their linings 47.03.21 secretory organs (glands) 47.03.21.01 mammary gland 47.03.21.02 salivary gland 47.03.21.03 endocrine organ 47.03.21.03.01 adrenal gland 47.03.21.03.02 pancreatic islet 47.03.21.03.03 parathyroid 47.03.21.03.04 pineal gland 47.03.21.03.05 pituitary gland 47.03.21.03.06 thyroid gland 47.03.21.05 sweat (perspiratory) gland 70 SUBCELLULAR LOCALIZATION 70.01 cell wall 70.02 eukaryotic plasma membrane / membrane attached 70.02.01 eukaryotic intracellular plasma membrane 70.03 cytoplasm 70.04 cytoskeleton 70.04.03 actin cytoskeleton 70.04.05 microtubule cytoskeleton 70.04.07 intermediate filaments 70.05 centrosome 70.06 cell junction 70.06.03 cell-substrate adherens junction 70.06.04 intercellular junction (gap junction/adherens junction) 70.07 endoplasmic reticulum 70.08 Golgi 70.09 intracellular transport vesicles 70.10 nucleus 70.10.03 chromosome 70.10.04 centromere / kinetochore 70.10.05 nuclear membrane 70.10.06 nuclear matrix 70.10.07 nucleolus 70.10.09 nuclear speckles 70.16 mitochondrion 70.16.01 mitochondrial outer membrane 70.16.03 mitochondrial intermembrane space 70.16.05 mitochondrial inner membrane 70.16.07 mitochondrial matrix 70.19 peroxisome 70.22 endosome 70.25 vacuole or lysosome 70.26 plastid 70.26.03 chloroplast 70.26.05 amyloplast 70.26.07 chromoplast 70.26.09 elaioplast 70.26.11 etioplast 70.26.13 leucoplast 70.27 extracellular / secretion proteins 70.27.01 extracellular matrix component 70.27.03 cell membrane or cell wall attached 70.28 periplasmatic space 70.29 bud / growth tip 70.30 prokaryotic cytoplasmic membrane 70.32 flagellum 70.33 pilus/fimbria 70.34 prokaryotic cell envelope component 70.34.01 bacterial outer membrane (only present in Gram- bacteria) 70.34.03 capsule and slime layer 70.34.05 S-Layer 70.34.07 peptidoglycan layer or other prokaryotic cell wall 70.34.09 spore or cyst coat 70.35 prokaryotic intracytoplasmic membrane 70.35.03 prokaryotic vesicular intracytoplasmic membrane 70.35.05 prokaryotic tubular intracytoplasmic membrane 70.35.07 prokaryotic thylakoid-like and thylakoid membrane 70.36 prokaryotic cell inclusions 70.36.03 carboxysomes 70.36.05 gas vesicles 70.36.07 sulfur globules or magnetosomes 70.36.09 bacteriocins, rhapidosomes and protein crystals 70.37 prokaryotic nucleoid 73 CELL TYPE LOCALIZATION 73.01 fungal / microorganismic cell type 73.01.02 prokaryotic cell type 73.01.02.01 free living cell or mycelium 73.01.02.02 sporangial or cystophor cell 73.01.02.03 heterocyste 73.01.02.05 spores and other resting cell types 73.01.02.05.01 endospore 73.01.02.05.03 exospore, cyst, akinete or other resting cells 73.01.02.11 swarmer and other mobile cells 73.01.03 fungal and other eukaryotic cell types 73.01.03.01 free swimming or amoeboid cell 73.01.03.02 mycelial or yeast-like cell 73.01.03.03 thallic, plasmodial or sporangiophore cell 73.01.03.07 conidia 73.01.03.09 asco- basidio- or zygospore 73.02 plant cell type 73.02.01 stem cell/meristematic cell 73.02.05 specialized epidermal cell 73.02.05.01 stomata/guard cell 73.02.05.02 plant hair cell (trichome e.g. cotton) 73.02.05.03 root hair 73.02.07 storage cell 73.02.09 vascular cell 73.02.09.01 sieve cell (phloem) 73.02.09.02 companion cell (phloem) 73.02.09.03 vessel element (xylem) 73.02.13 strengthening cell 73.02.13.01 sclerenchyma cell(dead) 73.02.13.02 collenchyma cell (living) 73.02.17 gametophytic cell 73.02.17.01 male gametophyte 73.02.17.01.01 generative pollen cell 73.02.17.02 female gametophyte 73.02.17.02.01 oocyte 73.02.17.02.03 central cell (2n) 73.02.19 secretory cell 73.03 animal cell type 73.03.01 stem cell (toti- or pluripotent) 73.03.02 germ cell 73.03.03 pigment cell 73.03.07 oxygen transporting cell (erythrocyte, etc.) 73.03.09 immune cell 73.03.09.01 T-cell 73.03.09.03 B-cell 73.03.09.05 macrophage 73.03.09.07 dendritic cell 73.03.11 glia cell 73.03.13 neuron 73.03.15 secretory cell (mastcell, endocrine cell, etc.) 73.03.17 structural cell of tissue (fibroblast, osteoblast, etc.) 73.03.18 storage cell (lipocyte, etc.) 73.03.19 extracellular matrix forming cell (fibrocyte, chondrocyte, osteocyte) 73.03.21 extracellular matrix degrading cell (chondroclast, osteoclast) 73.03.23 sensory cell 75 TISSUE LOCALIZATION 75.01 fungal/microorganismic tissue 75.01.01 reproductive tissue 75.01.10 thallic tissue 75.01.11 plectenchymatic tissue and tissue of primitive thalli (e.g. higher fungi) 75.02 plant tissue 75.02.01 meristematic tissue 75.02.01.01 shoot apical meristem 75.02.01.02 root meristem 75.02.05 parenchyma 75.02.09 dermal tissue 75.02.09.01 epidermis 75.02.09.03 rhizodermis 75.02.09.05 secondary dermal tissue (cork, phellem) 75.02.09.07 endodermis (with casparian band) 75.02.13 vascular tissue 75.02.15 thallus 75.03 animal tissue 75.03.03 proliferative tissue 75.03.03.01 bone marrow 75.03.04 adipose tissue 75.03.05 connective tissue 75.03.05.01 loose connective tissue / soft tissue 75.03.05.03 fibrous connective tissue (tendons, ligaments) 75.03.06 cartilage 75.03.07 bone 75.03.08 whole blood and lymph 75.03.09 epithelium 75.03.12 muscle 75.03.12.01 striated muscle 75.03.12.02 smooth muscle 75.03.12.03 heart muscle 75.03.15 reproductive tissue 75.03.17 nervous tissue 75.03.19 glandular tissue 77 ORGAN LOCALIZATION 77.01 fungal organ 77.01.01 hyphe 77.01.03 reproductive organ 77.01.03.01 fruit body 77.02 plant organ 77.02.01 shoot 77.02.01.01 stem 77.02.01.02 leaf 77.02.01.03 flower 77.02.01.03.01 sepal 77.02.01.03.02 petal 77.02.01.03.03 anther 77.02.01.03.04 carpel 77.02.01.04 fruit 77.02.01.05 seed 77.02.01.05.01 embryo 77.02.01.05.02 endosperm 77.02.01.06 rhizome (potato tuber/onion) 77.02.02 root 77.03 animal organ 77.03.01 nervous system 77.03.01.01 central nervous system 77.03.01.01.01 brain 77.03.01.01.01.01 cerebrum 77.03.01.01.01.02 cerebellum 77.03.01.02 peripheral nervous system 77.03.02 sensory organs 77.03.02.01 ear 77.03.02.02 eye 77.03.02.03 nose 77.03.02.04 tongue 77.03.02.05 skin 77.03.03 vascular organs 77.03.03.01 heart 77.03.03.02 vessels 77.03.05 immune system organs 77.03.05.01 thymus 77.03.05.02 spleen 77.03.05.03 lymphatic system 77.03.07 excretory apparatus 77.03.07.01 kidney 77.03.07.03 malphigi 77.03.07.05 pronephros (sensu Invertebrata) 77.03.07.07 metanephros (sensu Invertebrata) 77.03.09 respiratory system 77.03.09.01 lung 77.03.09.03 gill 77.03.09.05 trachea (sensu Insecta) 77.03.11 gastro-intestinal system 77.03.11.01 teeth 77.03.11.02 oesophagus 77.03.11.03 stomach 77.03.11.05 intestine 77.03.11.07 liver 77.03.11.09 pancreas 77.03.11.11 gastro-intestinal system accessory organs 77.03.13 dermis/cuticula 77.03.13.05 hair / feather follicule 77.03.15 reproductive apparatus 77.03.15.01 female gonad (ovary) 77.03.15.02 oviduct 77.03.15.04 uterus 77.03.15.04.03 cervix 77.03.15.05 placenta 77.03.15.07 male gonad (testis) 77.03.15.09 prostate 77.03.17 skeletal system 77.03.19 non organ cavities and their linings 77.03.21 secretory organs (glands) 77.03.21.01 mammary gland 77.03.21.02 salivary gland 77.03.21.03 endocrine organ 77.03.21.03.01 adrenal gland 77.03.21.03.02 pancreatic islet 77.03.21.03.03 parathyroid 77.03.21.03.04 pineal gland 77.03.21.03.05 pituitary gland 77.03.21.03.06 thyroid gland 77.03.21.05 sweat (perspiratory) gland 78 ubiquitous expression 98 CLASSIFICATION NOT YET CLEAR-CUT 99 UNCLASSIFIED PROTEINS