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DGPsubNet: Drug-Gene-Disease coherent SUBNETworks

  • Version 0.0.1
  • Last updated: Oct. 12, 2013

References#

  • Lin Wang, Yong Wang, Qinghua Hu and Shao Li. Exploring drug-gene-disease coherent subnetworks for elucidating drug-disease associations. In submission.

Motivation#

How to analyze transcriptional response data to identify meaningful gene modules shared by both drugs and diseases is still a critical issue to elucidate the molecular basis of drug-disease associations.

Method#

Here, we propose the drug-gene-disease coherent subnetwork concept to group the biological function related drugs, diseases and genes. Based on disease-related and drug-induced transcriptional response profiles, we develop a multiple non-negative matrix factorization method to identify drug-gene-disease coherent subnetworks. Additional heterogeneous data are simultaneously integrated in a regularized manner. Meanwhile, the sparsity penalties are employed to achieve modular solutions.

Software#

This version of the program is in very preliminary stage and provided just for testing purpose. The program is still under development.

Data#


Category: Supplementary Software

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DGPsubNet.rar 155,271.6 kB 1 13-Oct-2013 04:51 YongWang
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« This particular version was published on 12-Oct-2013 14:57 by YongWang.